Adolfo Ramirez-Zamora

Adolfo Ramirez-Zamora, MD

Professor Of Neurology & Division Chief Movement Disorders

Department: MD-NEUROLOGY-MOVEMENT DISORDER
Business Phone: (352) 294-5400
Business Email: aramirezzamora@ufl.edu

About Adolfo Ramirez-Zamora

I’m a current associate professor of neurology, as well as the program director and division chief of movement disorders at the Norman Fixel Institute for Neurological Diseases at the University of Florida. The Fixel Institute is part of the Center for Translational Research in Neurodegenerative Diseases and the McKnight Brain Institute at UF. Prior to joining UF, I practiced neurology at the Parkinson’s Disease and Movement Disorders Center at Albany Medical Center, where I served as an associate professor of neurology and the Philly E. Dake endowed chair in movement disorders.

I completed my neurology residency at Loyola University Chicago, followed by a fellowship in movement disorders at the University of California San Francisco. My unique areas of expertise encompass management of the entire spectrum of movement disorders, cerebellar ataxias and the use of botulinum toxin injections, along with deep brain stimulation (DBS) for the treatment of movement disorders.

My research interests include exploring neurophysiological brain changes observed in these conditions, and the use of neuromodulation for the treatment of uncommon neurological diseases. My clinical interests include developing new therapeutic modalities and novel neuromodulation techniques in the field of movement disorders.

I serve on the leadership of the Parkinson’s Foundation’s Hispanic Parkinson’s Advisory Council, as well as the steering committee of the Parkinson’s Outcomes Project. I also served as a member of the Diversity Leadership Program and Science Committee at the American Academy of Neurology (AAN), and I am an active member of the Ataxia Foundation, the Movement Disorders Society, the Parkinson Study Group, and the Huntington Study Group.

Accomplishments

Diversity Leadership Program Award recipient
2015 · American Academy of Neurology
NINDS Clinical Trials Methodology Course award recipient
2015 · NINDS
Richard Tyler Fellowship Award recipient
2015 · American Academy of Neurology
Phyllis E. Dake Endowed Chair in Movement Disorders
2014 · Albany Medical Center, Neurosciences Institute
Dentinger Award
2013 · Albany Medical Center, Neurosciences Institute

Teaching Profile

Courses Taught
2021
MDC7800 Neurology Clerkship
2023-2024
BMS6020 Clinical Neuroscience

Board Certifications

  • Neurology
    American Board of Psychiatry and Neurology

Clinical Profile

Specialties
  • Neurology
Areas of Interest
  • Ataxia
  • Dystonia
  • Essential tremor
  • Movement – uncontrollable
  • Movement – uncontrolled or slow
  • Movement – uncoordinated
  • Movement – unpredictable or jerky
  • Tremor disorders

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-9253-3899

Publications

2024
Deep learning predicts prevalent and incident Parkinson’s disease from UK Biobank fundus imaging.
Scientific reports. 14(1) [DOI] 10.1038/s41598-024-54251-1. [PMID] 38351326.
2024
Impacts of Deep Brain Stimulation of the Globus Pallidus Internus on Swallowing: A Retrospective, Cross-Sectional Study.
Dysphagia. [DOI] 10.1007/s00455-023-10660-4. [PMID] 38236261.
2023
Applications of Transcranial Magnetic Stimulation for Understanding and Treating Dystonia.
Advances in neurobiology. 31:119-139 [DOI] 10.1007/978-3-031-26220-3_7. [PMID] 37338699.
2023
Brain Recording Analysis and Visualization Online (BRAVO): An open-source visualization tool for deep brain stimulation data.
Brain stimulation. 16(3):793-797 [DOI] 10.1016/j.brs.2023.04.018. [PMID] 37100201.
2023
Centromedian-parafascicular complex deep brain stimulation improves motor symptoms in rapid onset Dystonia-Parkinsonism (DYT12-ATP1A3).
Brain stimulation. 16(5):1310-1312 [DOI] 10.1016/j.brs.2023.08.021. [PMID] 37634624.
2023
Does in-vehicle automation help individuals with Parkinson’s disease? A preliminary analysis.
Frontiers in neurology. 14 [DOI] 10.3389/fneur.2023.1225751. [PMID] 37900602.
2023
Interactive mobile application for Parkinson’s disease deep brain stimulation (MAP DBS): An open-label, multicenter, randomized, controlled clinical trial.
Parkinsonism & related disorders. 109 [DOI] 10.1016/j.parkreldis.2023.105346. [PMID] 36966051.
2023
Meta-analysis of Association between Newer Glucose-Lowering Drugs and Risk of Parkinson’s Disease.
Movement disorders clinical practice. 10(11):1659-1665 [DOI] 10.1002/mdc3.13893. [PMID] 37982117.
2023
The Interface between Inflammatory Bowel Disease, Neuroinflammation, and Neurological Disorders.
Seminars in neurology. 43(4):572-582 [DOI] 10.1055/s-0043-1771467. [PMID] 37562450.
2023
Therapies for Parkinson’s disease and the gut microbiome: evidence for bidirectional connection.
Frontiers in aging neuroscience. 15 [DOI] 10.3389/fnagi.2023.1151850. [PMID] 37323145.
2023
Utilization, surgical populations, centers, coverages, regional balance, and their influential factors of deep brain stimulation for Parkinson’s disease: a large-scale multicenter cross-sectional study from 1997 to 2021.
International journal of surgery (London, England). 109(11):3322-3336 [DOI] 10.1097/JS9.0000000000000603. [PMID] 37463002.
2023
Weight and survival after deep brain stimulation for Parkinson’s disease.
Parkinsonism & related disorders. 115 [DOI] 10.1016/j.parkreldis.2023.105810. [PMID] 37660542.
2022
A randomized clinical trial of burst vs. spaced physical therapy for Parkinsons disease.
Parkinsonism & related disorders. 97:57-62 [DOI] 10.1016/j.parkreldis.2022.02.021. [PMID] 35325665.
2022
COVID-19 and Integrated Multidisciplinary Care Model in Parkinson’s Disease: Literature Review & Future Perspectives
Behavioral Sciences. 12(11) [DOI] 10.3390/bs12110447. [PMID] 36421743.
2022
DAT and TH expression marks human Parkinson’s disease in peripheral immune cells.
NPJ Parkinson's disease. 8(1) [DOI] 10.1038/s41531-022-00333-8. [PMID] 35672374.
2022
Editorial: Deep Brain Stimulation Think Tank: Updates in Neurotechnology and Neuromodulation, Volume II.
Frontiers in human neuroscience. 16 [DOI] 10.3389/fnhum.2022.912730. [PMID] 35721359.
2022
Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic review.
NPJ Parkinson's disease. 8(1) [DOI] 10.1038/s41531-022-00339-2. [PMID] 35697709.
2022
Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making
Tremor and Other Hyperkinetic Movements. 12(1) [DOI] 10.5334/tohm.683. [PMID] 35651920.
2022
Functional characterization of the biogenic amine transporters on human macrophages
JCI Insight. 7(4) [DOI] 10.1172/jci.insight.151892. [PMID] 35015729.
2022
Levodopa-induced dyskinesia: a historical review of Parkinson’s disease, dopamine, and modern advancements in research and treatment
Journal of Neurology. 269(6):2892-2909 [DOI] 10.1007/s00415-022-10963-w. [PMID] 35039902.
2022
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury.
Frontiers in human neuroscience. 16 [DOI] 10.3389/fnhum.2022.813387. [PMID] 35308605.
2022
RCT protocol for driving performance in people with Parkinson’s using autonomous in-vehicle technologies.
Contemporary clinical trials communications. 28 [DOI] 10.1016/j.conctc.2022.100954. [PMID] 35812823.
2022
Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation.
Brain sciences. 12(8) [DOI] 10.3390/brainsci12081054. [PMID] 36009117.
2022
Safety of deep brain stimulation in pregnancy: A comprehensive review.
Frontiers in human neuroscience. 16 [DOI] 10.3389/fnhum.2022.997552. [PMID] 36248692.
2022
Subacute tremor and ataxia: Diligence in pursuit of a diagnosis.
Parkinsonism & related disorders. 104:129-131 [DOI] 10.1016/j.parkreldis.2022.05.016. [PMID] 35718685.
2022
The use of virtual reality to modify and personalize interior home features in Parkinson’s disease.
Experimental gerontology. 159 [DOI] 10.1016/j.exger.2022.111702. [PMID] 35038568.
2022
Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review
Neuromodulation: Technology at the Neural Interface. 25(6):796-803 [DOI] 10.1111/ner.13220.
2021
Advances and Future Directions of Neuromodulation in Neurologic Disorders.
Neurologic clinics. 39(1):71-85 [DOI] 10.1016/j.ncl.2020.09.004. [PMID] 33223090.
2021
Author Correction: TNFα increases tyrosine hydroxylase expression in human monocytes.
NPJ Parkinson's disease. 7(1) [DOI] 10.1038/s41531-021-00212-8. [PMID] 34341346.
2021
Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer’s Disease.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.645584. [PMID] 34122027.
2021
Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation.
Brain : a journal of neurology. 144(6):1774-1786 [DOI] 10.1093/brain/awab074. [PMID] 33889943.
2021
Corrigendum to: Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation.
Brain : a journal of neurology. 144(8) [DOI] 10.1093/brain/awab192. [PMID] 34115824.
2021
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.765150. [PMID] 34658825.
2021
Deep brain stimulation programming strategies: segmented leads, independent current sources, and future technology
Expert Review of Medical Devices. 18(9):875-891 [DOI] 10.1080/17434440.2021.1962286.
2021
Editorial: Advances in Functional Neurosurgery.
Frontiers in neurology. 12 [DOI] 10.3389/fneur.2021.812100. [PMID] 34975742.
2021
Editorial: Managing Parkinson’s Disease With a Multidisciplinary Perspective.
Frontiers in neurology. 12 [DOI] 10.3389/fneur.2021.799017. [PMID] 34899588.
2021
Effect of a Mediterranean diet intervention on gastrointestinal function in Parkinson’s disease (the MEDI-PD study): study protocol for a randomised controlled trial.
BMJ open. 11(9) [DOI] 10.1136/bmjopen-2021-053336. [PMID] 34551955.
2021
Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease: A Randomized Clinical Trial.
JAMA neurology. 78(3):312-320 [DOI] 10.1001/jamaneurol.2020.4725. [PMID] 33315105.
2021
Expediting telehealth use in clinical research studies: recommendations for overcoming barriers in North America.
NPJ Parkinson's disease. 7(1) [DOI] 10.1038/s41531-021-00177-8. [PMID] 33846349.
2021
Geospatial Analysis of Persons with Movement Disorders Living in Underserved Regions
Tremor and Other Hyperkinetic Movements. 11(1) [DOI] 10.5334/tohm.635. [PMID] 34513276.
2021
Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson’s Disease: Expert Review and Commentary.
Neurology and therapy. 10(1):7-30 [DOI] 10.1007/s40120-020-00220-5. [PMID] 33140286.
2021
Home Health Management of Parkinson Disease Deep Brain Stimulation: A Randomized Clinical Trial.
JAMA neurology. 78(8):972-981 [DOI] 10.1001/jamaneurol.2021.1910. [PMID] 34180949.
2021
Mediterranean Diet Adherence in People With Parkinson’s Disease Reduces Constipation Symptoms and Changes Fecal Microbiota After a 5-Week Single-Arm Pilot Study.
Frontiers in neurology. 12 [DOI] 10.3389/fneur.2021.794640. [PMID] 35002935.
2021
Pallidal Connectivity Profiling of Stimulation-Induced Dyskinesia in Parkinson’s Disease.
Movement disorders : official journal of the Movement Disorder Society. 36(2):380-388 [DOI] 10.1002/mds.28324. [PMID] 33002233.
2021
Patterns and predictors of referrals to allied health services for individuals with Parkinson’s disease: A Parkinson’s foundation (PF) QII study.
Parkinsonism & related disorders. 83:115-122 [DOI] 10.1016/j.parkreldis.2020.11.024. [PMID] 33339716.
2021
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.
Frontiers in human neuroscience. 15 [DOI] 10.3389/fnhum.2021.644593. [PMID] 33953663.
2021
The Gut-Brain Axis and Its Relation to Parkinson’s Disease: A Review.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.782082. [PMID] 35069178.
2021
TNFα increases tyrosine hydroxylase expression in human monocytes.
NPJ Parkinson's disease. 7(1) [DOI] 10.1038/s41531-021-00201-x. [PMID] 34285243.
2021
Weight Change After Subthalamic Nucleus Deep Brain Stimulation in Patients With Isolated Dystonia.
Frontiers in neurology. 12 [DOI] 10.3389/fneur.2021.632913. [PMID] 33716933.
2020
A novel approach to study markers of dopamine signaling in peripheral immune cells.
Journal of immunological methods. 476 [DOI] 10.1016/j.jim.2019.112686. [PMID] 31634479.
2020
A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia.
Journal of neurology. 267(5):1278-1290 [DOI] 10.1007/s00415-020-09703-9. [PMID] 31938862.
2020
An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.00162. [PMID] 32733215.
2020
Brain Atrophy Following Deep Brain Stimulation: Management of a Moving Target.
Tremor and other hyperkinetic movements (New York, N.Y.). 10 [DOI] 10.5334/tohm.546. [PMID] 33133768.
2020
Cognitive Outcomes for Essential Tremor Patients Selected for Thalamic Deep Brain Stimulation Surgery Through Interdisciplinary Evaluations.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.578348. [PMID] 33362489.
2020
Combined Unilateral Subthalamic Nucleus and Contralateral Globus Pallidus Interna Deep Brain Stimulation for Treatment of Parkinson Disease: A Pilot Study of Symptom-Tailored Stimulation.
Neurosurgery. 87(6):1139-1147 [DOI] 10.1093/neuros/nyaa201. [PMID] 32459849.
2020
Dissociative Tremor Response with Pallidal Deep Brain Stimulation in Parkinson’s Disease.
Tremor and other hyperkinetic movements (New York, N.Y.). 10 [DOI] 10.5334/tohm.568. [PMID] 33362947.
2020
Dysarthria and Speech Intelligibility Following Parkinson’s Disease Globus Pallidus Internus Deep Brain Stimulation.
Journal of Parkinson's disease. 10(4):1493-1502 [DOI] 10.3233/JPD-202246. [PMID] 32955467.
2020
Editorial: Patient Empowerment and Person-Centered Care in Movement Disorders.
Frontiers in neurology. 11 [DOI] 10.3389/fneur.2020.00317. [PMID] 32411083.
2020
High-dose Botulinum Toxin Therapy: Safety, Benefit, and Endurance of Efficacy.
Tremor and other hyperkinetic movements (New York, N.Y.). 10 [DOI] 10.7916/tohm.v0.749. [PMID] 32149014.
2020
Hospital Management of Parkinson Disease Patients.
Clinics in geriatric medicine. 36(1):173-181 [DOI] 10.1016/j.cger.2019.09.009. [PMID] 31733698.
2020
Long-term Parkinson’s disease quality of life after staged DBS: STN vs GPi and first vs second lead.
NPJ Parkinson's disease. 6 [DOI] 10.1038/s41531-020-0115-3. [PMID] 32656315.
2020
Motor outcomes and adverse effects of deep brain stimulation for dystonic tremor: A systematic review.
Parkinsonism & related disorders. 76:32-41 [DOI] 10.1016/j.parkreldis.2020.06.008. [PMID] 32559631.
2020
Multidisciplinary Telemedicine Care for Tourette Syndrome: Minireview.
Frontiers in neurology. 11 [DOI] 10.3389/fneur.2020.573576. [PMID] 33391146.
2020
Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
Annals of Clinical and Translational Neurology. 7(1):59-68 [DOI] 10.1002/acn3.50961. [PMID] 31813194.
2020
Parkinson’s disease motor subtype changes during 20 years of follow-up.
Parkinsonism & related disorders. 76:104-107 [DOI] 10.1016/j.parkreldis.2019.05.024. [PMID] 31129020.
2020
Parkinson’s disease motor subtypes and bilateral GPi deep brain stimulation: One-year outcomes.
Parkinsonism & related disorders. 75:7-13 [DOI] 10.1016/j.parkreldis.2020.05.004. [PMID] 32428801.
2020
Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.00054. [PMID] 32292333.
2020
Quality of life outcomes after deep brain stimulation in dystonia: A systematic review.
Parkinsonism & related disorders. 70:82-93 [DOI] 10.1016/j.parkreldis.2019.11.016. [PMID] 31767450.
2020
Quality of life outcomes after globus pallidus internus deep brain stimulation in idiopathic or inherited isolated dystonia: a meta-analysis.
Journal of neurology, neurosurgery, and psychiatry. 91(9):938-944 [DOI] 10.1136/jnnp-2019-322575. [PMID] 32732389.
2020
STN Versus GPi Deep Brain Stimulation for Action and Rest Tremor in Parkinson’s Disease.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.578615. [PMID] 33192410.
2020
Three-Year Gait and Axial Outcomes of Bilateral STN and GPi Parkinson’s Disease Deep Brain Stimulation.
Frontiers in human neuroscience. 14 [DOI] 10.3389/fnhum.2020.00001. [PMID] 32116598.
2019
Acute Effects of Subthalamic Deep Brain Stimulation on Motor Outcomes in Parkinson’s Disease; 13 Year Follow Up.
Frontiers in neurology. 10 [DOI] 10.3389/fneur.2019.00689. [PMID] 31293511.
2019
Challenges in Defining Inappropriate Medication Use in Parkinson Disease Dementia.
JAMA neurology. 76(1):17-19 [DOI] 10.1001/jamaneurol.2018.2826. [PMID] 30285044.
2019
Gait in Parkinson’s Disease.
Parkinson's disease. 2019 [DOI] 10.1155/2019/1962123. [PMID] 31772732.
2019
Is Interferon Therapy for Hepatitis C Infection a Treatable Risk Factor for Parkinson Disease?
JAMA neurology. 76(9):1006-1007 [DOI] 10.1001/jamaneurol.2019.1377. [PMID] 31168561.
2019
New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson’s Disease.
Frontiers in neurology. 10 [DOI] 10.3389/fneur.2019.00659. [PMID] 31275238.
2019
Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics.
Frontiers in neuroscience. 13 [DOI] 10.3389/fnins.2019.00936. [PMID] 31572109.
2019
Rescue levodopa‐carbidopa intestinal gel (LCIG) therapy in Parkinson’s disease patients with suboptimal response to deep brain stimulation
Annals of Clinical and Translational Neurology. 6(10):1989-1995 [DOI] 10.1002/acn3.50889. [PMID] 31518070.
2019
STN vs. GPi deep brain stimulation for tremor suppression in Parkinson disease: A systematic review and meta-analysis.
Parkinsonism & related disorders. 58:56-62 [DOI] 10.1016/j.parkreldis.2018.08.017. [PMID] 30177491.
2018
Anatomical Correlates of Uncontrollable Laughter With Unilateral Subthalamic Deep Brain Stimulation in Parkinson’s Disease.
Frontiers in neurology. 9 [DOI] 10.3389/fneur.2018.00341. [PMID] 29887826.
2018
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients With Parkinson’s Disease: Executive Summary.
Neurosurgery. 82(6):753-756 [DOI] 10.1093/neuros/nyy037. [PMID] 29538685.
2018
Globus Pallidus Interna or Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease: A Review.
JAMA neurology. 75(3):367-372 [DOI] 10.1001/jamaneurol.2017.4321. [PMID] 29356826.
2018
Impulse control disorders in Parkinson’s: Sleep disorders and nondopaminergic associations.
Brain and behavior. 8(3) [DOI] 10.1002/brb3.904. [PMID] 29541533.
2018
Is deep brain stimulation therapy underutilized for movement disorders?
Expert review of neurotherapeutics. 18(12):899-901 [DOI] 10.1080/14737175.2018.1538791. [PMID] 30350730.
2018
King’s Parkinson’s Disease Pain Scale for Assessment of Pain Relief Following Deep Brain Stimulation for Parkinson’s Disease.
Neuromodulation : journal of the International Neuromodulation Society. 21(6):617-622 [DOI] 10.1111/ner.12778. [PMID] 29608802.
2018
Neuromedicine Service and Science Hub Model.
JAMA neurology. 75(3):271-272 [DOI] 10.1001/jamaneurol.2017.3976. [PMID] 29297000.
2018
Pallidal deep brain stimulation and intraoperative neurophysiology for treatment of poststroke hemiballism
Annals of Clinical and Translational Neurology. 5(7):865-869 [DOI] 10.1002/acn3.573. [PMID] 30009204.
2018
Parkinson Disease: Current and Emerging Treatment Strategies.
The Journal of clinical psychiatry. 79(3) [DOI] 10.4088/JCP.PP17030TX1C. [PMID] 29999254.
2018
Potential indications for deep brain stimulation in neurological disorders: an evolving field
European Journal of Neurology. 25(3) [DOI] 10.1111/ene.13548.
2018
Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.
Movement disorders clinical practice. 5(1):75-82 [DOI] 10.1002/mdc3.12565. [PMID] 30363386.
2018
Ventral pallidum deep brain stimulation attenuates acute partial, generalized and tonic-clonic seizures in two rat models.
Epilepsy research. 142:36-44 [DOI] 10.1016/j.eplepsyres.2018.03.010. [PMID] 29549795.
2017
A Comparison of Unilateral Deep Brain Stimulation (DBS), Simultaneous Bilateral DBS, and Staged Bilateral DBS Lead Accuracies.
Neuromodulation : journal of the International Neuromodulation Society. 20(5):478-483 [DOI] 10.1111/ner.12588. [PMID] 28370879.
2017
Considering Spastic Paraplegia Type 7 and Adult-Onset Alexander Disease.
JAMA neurology. 74(7):868-869 [DOI] 10.1001/jamaneurol.2017.0430. [PMID] 28459923.
2017
Effect of diazepam and yohimbine on neuronal activity in sham and hemiparkinsonian rats.
Neuroscience. 351:71-83 [DOI] 10.1016/j.neuroscience.2017.03.039. [PMID] 28385635.
2017
Effect of Eye Opening on Single-Unit Activity and Local Field Potentials in the Subthalamic Nucleus.
Neuromodulation : journal of the International Neuromodulation Society. 20(5):471-477 [DOI] 10.1111/ner.12606. [PMID] 28493348.
2017
Effect of low-frequency deep brain stimulation on sensory thresholds in Parkinson’s disease.
Journal of neurosurgery. 126(2):397-403 [DOI] 10.3171/2016.2.JNS152231. [PMID] 27104841.
2017
Evaluation of Quantitative Measurement Techniques for Head Tremor With Thalamic Deep Brain Stimulation.
Neuromodulation : journal of the International Neuromodulation Society. 20(5):464-470 [DOI] 10.1111/ner.12566. [PMID] 28145626.
2017
Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank.
Frontiers in neuroscience. 11 [DOI] 10.3389/fnins.2017.00734. [PMID] 29416498.
2017
In reply to: “Hyperhidrosis caused by deep brain stimulation in the posterior subthalamic area” by Patric Blomstedt MD, PhD.
Journal of the neurological sciences. 380 [DOI] 10.1016/j.jns.2017.07.025. [PMID] 28754236.
2017
Pallidal Deep Brain Stimulation for the Treatment of Levodopa-Responsive Juvenile Dystonia and Parkinsonism Secondary to SPG11 Mutation.
JAMA neurology. 74(1):127-128 [DOI] 10.1001/jamaneurol.2016.4297. [PMID] 27820618.
2017
Shaking Up the Debate: Ensuring the Ethical Use of DBS Intervention Criteria for Mid-Stage Parkinson’s Patients.
Neuromodulation : journal of the International Neuromodulation Society. 20(5):411-416 [DOI] 10.1111/ner.12608. [PMID] 28497554.
2016
Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation.
Tremor and other hyperkinetic movements (New York, N.Y.). 6 [DOI] 10.7916/D8S182JJ. [PMID] 27441097.
2016
Clinical outcome and intraoperative neurophysiology for focal limb dystonic tremor without generalized dystonia treated with deep brain stimulation.
Clinical neurology and neurosurgery. 150:169-176 [DOI] 10.1016/j.clineuro.2016.06.006. [PMID] 27685658.
2016
Deep brain stimulation for the treatment of uncommon tremor syndromes.
Expert review of neurotherapeutics. 16(8):983-97 [DOI] 10.1080/14737175.2016.1194756. [PMID] 27228280.
2016
Deep Brain Stimulation of the Ventral Pallidum Attenuates Epileptiform Activity and Seizing Behavior in Pilocarpine-Treated Rats.
Brain stimulation. 9(2):285-95 [DOI] 10.1016/j.brs.2015.11.006. [PMID] 26723019.
2016
Evolving Concepts in Posterior Subthalamic Area Deep Brain Stimulation for Treatment of Tremor: Surgical Neuroanatomy and Practical Considerations.
Stereotactic and functional neurosurgery. 94(5):283-297 [PMID] 27728907.
2016
Hyperhidrosis associated with subthalamic deep brain stimulation in Parkinson’s disease: Insights into central autonomic functional anatomy.
Journal of the neurological sciences. 366:59-64 [DOI] 10.1016/j.jns.2016.04.045. [PMID] 27288777.
2016
Investigation of diazepam efficacy on anxiety-like behavior in hemiparkinsonian rats.
Behavioural brain research. 301:226-37 [DOI] 10.1016/j.bbr.2015.12.045. [PMID] 26748254.
2016
Reduction in DBS frequency improves balance difficulties after thalamic DBS for essential tremor.
Journal of the neurological sciences. 367:122-7 [DOI] 10.1016/j.jns.2016.06.001. [PMID] 27423573.
2016
Subthalamic deep brain stimulation alters neuronal firing in canonical pain nuclei in a 6-hydroxydopamine lesioned rat model of Parkinson’s disease.
Experimental neurology. 283(Pt A):298-307 [DOI] 10.1016/j.expneurol.2016.06.031. [PMID] 27373204.
2016
The Effects of Mechanical and Thermal Stimuli on Local Field Potentials and Single Unit Activity in Parkinson’s Disease Patients.
Neuromodulation : journal of the International Neuromodulation Society. 19(7):698-707 [DOI] 10.1111/ner.12453. [PMID] 27284636.
2016
Treatment of impulse control disorders in Parkinson’s disease: Practical considerations and future directions.
Expert review of neurotherapeutics. 16(4):389-99 [DOI] 10.1586/14737175.2016.1158103. [PMID] 26923084.
2015
Deep brain stimulation significantly decreases disability from low back pain in patients with advanced Parkinson’s disease.
Stereotactic and functional neurosurgery. 93(3):206-11 [DOI] 10.1159/000380827. [PMID] 25895600.
2015
Interleaved programming of subthalamic deep brain stimulation to avoid adverse effects and preserve motor benefit in Parkinson’s disease.
Journal of neurology. 262(3):578-84 [DOI] 10.1007/s00415-014-7605-3. [PMID] 25504447.
2015
Neurological picture. Bilateral pallidal and medial temporal lobe ischaemic lesions after opioid overdose.
Journal of neurology, neurosurgery, and psychiatry. 86(12):1383-4 [DOI] 10.1136/jnnp-2014-308730. [PMID] 25240058.
2015
Pallidal stimulation for Holmes tremor: clinical outcomes and single-unit recordings in 4 cases.
Journal of neurosurgery. 122(6):1306-14 [DOI] 10.3171/2015.2.JNS141098. [PMID] 25794341.
2015
Pediatric Acute Longitudinal Extensive Transverse Myelitis Secondary to Neuroborreliosis.
Case reports in neurology. 7(2):162-6 [DOI] 10.1159/000438696. [PMID] 26351447.
2015
Possible autoimmune association between herpes simplex virus infection and subsequent anti-N-methyl-d-aspartate receptor encephalitis: a pediatric patient with abnormal movements.
Pediatric neurology. 52(4):454-6 [DOI] 10.1016/j.pediatrneurol.2014.10.011. [PMID] 25661288.
2015
Response.
Journal of neurosurgery. 123(5):1349-50 [PMID] 26870866.
2015
The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA-lesioned rats.
The European journal of neuroscience. 42(4):2061-9 [DOI] 10.1111/ejn.12992. [PMID] 26082992.
2015
The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in Parkinson’s Disease Patients.
Stereotactic and functional neurosurgery. 93(4):265-70 [DOI] 10.1159/000381558. [PMID] 26066569.
2015
Treatable causes of cerebellar ataxia.
Movement disorders : official journal of the Movement Disorder Society. 30(5):614-23 [DOI] 10.1002/mds.26158. [PMID] 25757427.
2015
Unusual complications of deep brain stimulation.
Neurosurgical review. 38(2):245-52; discussion 252 [DOI] 10.1007/s10143-014-0588-9. [PMID] 25342239.
2014
Treatment of motor fluctuations in Parkinson’s disease: recent developments and future directions.
Expert review of neurotherapeutics. 14(1):93-103 [DOI] 10.1586/14737175.2014.868306. [PMID] 24328720.
2013
Autopsy proven peripheral nervous system neurolymphomatosis despite negative bilateral sural nerve biopsy.
Frontiers in neurology. 4 [DOI] 10.3389/fneur.2013.00197. [PMID] 24367352.
2013
Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat.
Journal of neurophysiology. 109(2):363-74 [DOI] 10.1152/jn.00311.2012. [PMID] 23076106.
2013
Intraparenchymal cyst development after deep brain stimulator placement.
Stereotactic and functional neurosurgery. 91(5):338-41 [DOI] 10.1159/000350021. [PMID] 23989490.
2010
Management of neurocysticercosis.
Neurological research. 32(3):229-37 [DOI] 10.1179/016164110X12644252260592. [PMID] 20406600.
2009
Brainstem cavernous malformations: a review with two case reports.
Arquivos de neuro-psiquiatria. 67(3B):917-21 [PMID] 19838533.

Grants

Aug 2023 ACTIVE
Effects of deep brain stimulation (DBS) on laryngeal function and associated behaviors in Parkinson Disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jan 2023 ACTIVE
CTOA Ramirez-Zamora – Residuals
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Nov 2021 – Sep 2023
Long-Term Clinical Outcomes in Advanced PD Patients with Severe Motor Fluctuations Managed with Oral Dopaminergic Therapies Versus Patients Switched to Device-Aided Therapies
Role: Principal Investigator
Funding: ABBVIE
Nov 2021 – Jun 2023
A PHASE IIB, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF INTRAVENOUS PRASINEZUMAB IN PARTICIPANTS WITH EARLY PARKINSON'S DISEASE
Role: Principal Investigator
Funding: GENENTECH INC
Oct 2021 ACTIVE
Collaborative Research: SCH: Trustworthy and Explainable AI for Neurodegenerative Diseases
Role: Co-Investigator
Funding: NATL SCIENCE FOU
Apr 2021 ACTIVE
Web-based Automated Imaging Differentiation of Parkinsonism
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Mar 2021 – Mar 2023
AURICULAR MUSCLE ZONE STIMULATION FOR PARKINSON DISEASE
Role: Principal Investigator
Funding: STOPARKINSON HEALTHCARE SYSTEMS
Oct 2020 ACTIVE
Adaptive DBS Algorithm for Personalized Therapy in Parkinsons Disease (ADAPT-PD) Trial
Role: Principal Investigator
Funding: MEDTRONIC INC
Sep 2020 – Aug 2023
Driving Performance of People with Parkinson's using Autonomous Vehicle Technologies
Role: Co-Investigator
Funding: ADMIN FOR COMMUNITY LIVING
May 2020 ACTIVE
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinsons Disease
Role: Principal Investigator
Funding: RHO INC via NEURALY
Apr 2020 – Sep 2021
A Study to Evaluate NYX-458 in Subjects with Mild Cognitive Impairment Associated with Parkinson's Disease
Role: Principal Investigator
Funding: WORLDWIDE CLINICAL TRIALS via APTINYX
Jan 2020 – May 2023
A Prospective, Randomized, Cross-Over Home-Use Study of TOPS DBS for the Treatment of Parkinsons Disease
Role: Principal Investigator
Funding: DEEP BRAIN INNOVATIONS LLC
Dec 2019 ACTIVE
LRRK2-Synuclein Interactions with Gut Inflammation in PD Pathogenesis
Role: Co-Investigator
Funding: PARKINSONS FOU
Sep 2019 ACTIVE
Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor
Role: Co-Project Director/Principal Investigator
Funding: NATL INST OF HLTH NINDS
Sep 2019 ACTIVE
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3
Role: Co-Investigator
Funding: NORTHWESTERN UNIV via NATL INST OF HLTH NINDS
May 2019 ACTIVE
A 12-month double-blind, randomized, controlled study to evaluate the safety and efficacy of Deep Brain Stimulation of the fornix (DBS-f) in patients with mild probable Alzheimers Disease
Role: Principal Investigator
Funding: FUNCTIONAL NEUROMODULATION
May 2018 – Oct 2021
Effect of LY3154207 on Cognition in Mild-to-Moderate Parkinsons Disease Dementia (PDD)(The PRESENCE Study)
Role: Principal Investigator
Funding: LILLY USA
Nov 2017 – Aug 2020
A Randomized, Double-Blind, Placebo-Controlled, Phase IIa, Parallel Group, Two-Cohort Study to Define the Safety, Tolerability, and Clinical and Exploratory Biological Activity of the Chronic Administration of Nilotinib in Participants with Parkinsons Disease (PD)
Role: Principal Investigator
Funding: NORTHWESTERN UNIV via NOVARTIS US PHARMACEUTICALS
Aug 2017 – May 2023
Mechanisms of airway protection dysfunction in Parkinson's disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2009 ACTIVE
CTOA – Movement
Role: Principal Investigator
Funding: UNIV OF FLORIDA

Education

MD
2002 · Universidad Autónoma de Guadalajara

Contact Details

Phones:
Business:
(352) 294-5400
Emails:
Addresses:
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PO Box 100268
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3011 SW WILLISTON RD RM 1103
GAINESVILLE FL 32608